State of the art prediction of HIV-1 protease cleavage sites
نویسندگان
چکیده
منابع مشابه
State of the art prediction of HIV-1 protease cleavage sites
MOTIVATION Understanding the substrate specificity of human immunodeficiency virus (HIV)-1 protease is important when designing effective HIV-1 protease inhibitors. Furthermore, characterizing and predicting the cleavage profile of HIV-1 protease is essential to generate and test hypotheses of how HIV-1 affects proteins of the human host. Currently available tools for predicting cleavage by HIV...
متن کاملSequence analysis State of the art prediction of HIV-1 protease cleavage sites
Motivation: Understanding the substrate specificity of human immunodeficiency virus (HIV)-1 protease is important when designing effective HIV-1 protease inhibitors. Furthermore, characterizing and predicting the cleavage profile of HIV-1 protease is essential to generate and test hypotheses of how HIV-1 affects proteins of the human host. Currently available tools for predicting cleavage by HI...
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Several machine learning techniques, like neural networks, nonlinear support vector machines and decision trees, have been used to model the specificity of HIV-1 protease and to extract specific patterns from peptides cleaved by this protease. Despite many studies, no perfect rules are already known to determine the cleavage of a peptide by HIV-1 protease. These rules are useful for designing s...
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Recently, several works have approached the HIV-1 protease specificity problem by applying a number of classifier creation and combination methods, known as ensemble methods, from the field of machine learning. However, it is still difficult for researchers to choose the best method due to the lack of an effective comparison. For the first time we have made an extensive study on methods for fea...
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Developing an effective preventative vaccine against HIV-1 has proved to be a great challenge. The classical and proven vaccine approach has failed so far or produced a modest effect, new approaches are needed. In this study we evaluated the immunogenicity of the sequences around the protease cleavage sites (PCS) and the population coverage of a vaccine targeting HIV-1 PCS. The sequence conserv...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2014
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btu810